HPR NEWS

Our 2004-2006 publishing activities:

Pain/ Laser Algesimetry

1. Schaffler K., Seibel K., Thomsen M. and Edwards M., Effect of the New H1-Antagonist ReN1869 on the capsaicin-induced hyperalgesia in human skin: Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser, Drug Res. 54, No.3, 187-191, 2004

2. Schaffler K., Overcoming the challenges associated with pain measurement and treatment (presentation), (+ breakfast workshop: Reviewing the value of models and biomarkers in early development to assess pain), IIR Conference: Leveraging CNS Product Development, Amsterdam 31.3.-1.4. 2004

3. Schaffler K., Reitmeir P., Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia - using CO2-Laser-induced somatosensory evoked potentials from human skin in the state of capsaicin hyperalgesia, submitted for publication Drug Res., accepted 04/2004, in print for 10/2004

4. Seibel K., Schaffler K., Reeh P., Reitmeir P., Comparison of two different preparations of ibuprofen with regard to the time course of their analgesic effect - using laser somatosensory evoked potentials from UV-irritated skin in healthy volunteers, Drug Res. 54, No.8, 444-451, 2004

5. Klaus Schaffler, Peter Reitmeir, Andrea Gschanes, Udo Eggenreich, Comparison of the analgesic effects of NEODOLPASSE® with its compounds diclofenac and orphenadrine, a placebo-controlled study using Laser-induced somatosensory evoked potentials from human skin in the state of capsaicin hyperalgesia, Drugs R D, 6 (4): 189-199, 2005

Vigilance/Cognition and Others

6. Murck H., Uhr M., Schaffler K., Seibel K., Effects of Hypericum Extract (LI160) on the Change of Auditory Evoked Potentials by Cortisol Administration, Neuropsychobiology 2004;50(2):128-133 (DOI:10.1159/000079103)

7. Murck H., Spitznagel H., Ploch M., Seibel K., Schaffler K., Hypericum extract reverses S-ketamin-induced changes in AEPs in humans - implication for the treatment of schizophrenia, Biol Psychiatry 2006, 59: 440-445

8. B. Drewelow, K. Schaffler, P. Reitmeir, Superior interaction profile of pantoprazole vs. esomeprazole after single dose diazepam regarding pharmacodynamic (PD) and kinetic (PK) parameters, Poster, accepted at Congress of Canadian Association of Gastroenterology (CAG), Canadian Digestive Disease Week (CDDW) Banff Febr. 2006

9. B. Drewelow, K. Schaffler, Überlegenes Interaktionsprofil von Pantoprazol vs. Esomeprazol: Pharmakodynamik (PD) und -kinetik (PK) nach Diazepam Einzelgabe, Poster, akzeptiert beim 112. Kongress der Deutschen Gesellschaft für Innere Medizin (DGIM), Wiesbaden 2006

Our new experimental activities in 2005/2006:

Starting 2005 we added a new feature to our concept of "high resolution algesimetry" at HPR.

1. The routinely done pain relief measurements in the past - investigating quite a variety of analgesic compounds - were well established since the mid 80-ies at HPR, and performed by quantitative-objective Laser algesimetry (= Laser somatosensory evoked potentials, LSEPs). The respective hard- and software developments and adaptations enable the performance of high-throughput approaches to nociceptive, inflammatory and neurogenic pain - using normal skin, UV- and prostacyclin-, and capsaicin-irritated skin. These different skin modes depict different pain processing mechanisms with regard to the "primary" targets: nociception, "peripheral" hyperalgesia; peripheral and "central/spinal" hyperalgesia.

In this pain-inducing menue a "pure" central/spinal impact mode was still missing, and the subjective respectively semi-quantitative approaches to measure mechanical hyperalgesia (allodynia) by pin-prick, brush-evoked pain etc., e.g. via psychophysics, should be re-targeted to an objective-quantitative pain measurement paradigm.

Therefore we introduced "Mechano-sensory evoked potentials" (MSEPs).

This well-defined mechanical impact mode can be run as well on normal as on irritated skin, and offers the advantage of being a pure spinal hyperalgesia inducing tool. Thus we close the loop in investigation, respectively add a missing link to the experimental pain processing mode. Further details will be presented after having respective results available.

Starting late 2005 we added a new feature to our concept of electro-physiological evaluation of "basic CNS-activity".

2. We added a Cadwell Easy II 32-channel EEG machine to our measurement tools. This computer EEG allows to run standard and provocation EEG or (topographic) EEG brain mapping: The resting, vigilance-controlled, and task-related EEG can be recorded and its spectral power analysed for the evaluation of "non-specific" vigilance changes/ responses (e.g. spontaneous or drug-related fluctuations of vigilance - as with hypnotics and strong analgesics). Further additional provocation methods - as photic stimulation, hyperventilation and sleep deprivation - can be applied to detect dysrhythmic, epileptic/hyper-excitatory tendencies in subjects (s/w spike and wave detection). Up to 32 EEG-channels can be evaluated simultaneously.

3. In April 2006 we added a new technology to our CO2-Laser pain system: The movable laser benches were step-by-step replaced by complex systems consisting of flexible hollow-light-guides with 2- respectively 3-dimensional movable hand pieces (positioning in x/y and partly in z-axis) with integrated HeNe-target lasers. There exist only 2 manufacturers in the world for the technology of flexible hollow-light-guides for CO2-Lasers. Until the near past the transmission of CO2-Laser emission in the far-infrared spectrum was only possible in a straight ahead mode via relatively rigid and complicated joint-mirror systems (e.g. in surgery). This advanced flexible "light-guide" adaptation in pain research enhances the performance with different skin positions and types as well as the flexibility for diverse clinical purposes (e.g. use in diagnosis and treatment control of hypo- and hyperalgesic skin areas in DNP).

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