Measurement of skeleto-motor
functions: Tremor
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Usefulness of the methods
Measurement of tremor is of great importance for the
characterisation of antiparkinsonian drugs, of some psychotropic drugs which
may induce or reduce tremor and of new anti-asthmatic agents which may be advantageous
with regard to induction of tremor in comparison to older ß2-stimulants
and some preparations of theophylline.
Principle of the methods
Spectral tremor analysis:
With our spectral tremor analyser, a three
dimensio- nal accelerometer, frequency and amplitude of tremor can be measured
as a Fast Fourier Transformation power spectrum under relaxed, semi-intentional
and intentional skeletomotor conditions.
Handwriting test:
The volunteer creates and follows a continuous series of letters. The deviation
vectors of velocity and acceleration are recorded and evaluated. The test which
is very sensitive to the effect of tremor inducing or reducing drugs, assesses
excellently the visu-motor performance of voluntary and involuntary skeletomotor
movements ( eye-hand coordination ).
Advantages of
the methods
With the spectral tremor analysis and the hand writing
test we combine complete tremor analysis with testing of sensu-motor ability
as needed in every day life. On-line evaluation of our measurements allows for
prompt assessment and documentation of results.
Reference data
Data are available for ß2-mimetics, antiparkinsonian
drugs and acute administration of alcohol.
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